Three-dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging

Weiss, Stephan; Järmann, Thomas; Schmid, Peter; Staempfli, Philipp; Boesiger, Peter; Niederer, Peter; Caduff, Rosmarie; Bajka, Michael

doi:10.1002/ar.a.20274

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Three-dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging
Authors:	Weiss, Stephan Järmann, Thomas Schmid, Peter Staempfli, Philipp Boesiger, Peter Niederer, Peter Caduff, Rosmarie Bajka, Michael
DOI:	10.1002/ar.a.20274
Published in:	The Anatomical Record
Volume(Issue):	288A
Issue:	1
Page(s):	84
Pages to:	90
Issue Date:	2006
Publisher / Ed. Institution:	Wiley
ISSN:	1552-4884 1552-4892 0003-276X 1932-8494
Language:	English
Subjects:	Adult; Anisotropy; Diffusion Magnetic Resonance Imaging; Female; Humans; Immunohistochemistry; In vitro techniques; Middle aged; Skeletal muscle fibers; Myometrium
Subject (DDC):	610: Medicine and health
Abstract:	The global muscle and collagen fiber orientation in the human uterus has been analyzed hitherto by various standard microscopic techniques. However, no widely accepted model of the fiber architecture of the myometrium could be acquired. The purpose of the present study was to investigate the uterus by magnetic resonance (MR) diffusion tensor imaging (DTI) in a 3D macroscopic approach. Ex vivo MR DTI measurements were performed on five uteri from nonpregnant patients. The main diffusion directions reflecting the orientation of directional structures in the examined tissues were determined from diffusion-weighted spin-echo measurements. A fiber tracking algorithm was used to extrapolate the fiber architecture. The method was validated against histological slides and indirectly through the analysis of leiomyomas, which exhibit less anisotropy than normal myometrium. Significant anisotropy was found in most regions of all examined nonpregnant human uteri. But only two systems of fibers were found running circularly along the intramural part of the uterine tubes. They merged caudally and built a close fitting envelope of circular layers around the uterine cavity. On the cervix, circular fibers were observed in the outer part as well as mostly longitudinal fibers in the inner part. These results confirm the existence of directional structures in the complex fiber architecture of the human uterus. They also indicate that MR DTI is a beneficial and complementary tool to standard microscopic techniques to determine the intrinsic fiber architecture in human organs.
URI:	https://digitalcollection.zhaw.ch/handle/11475/5026
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	School of Engineering
Appears in collections:	Publikationen School of Engineering

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Weiss, S., Järmann, T., Schmid, P., Staempfli, P., Boesiger, P., Niederer, P., Caduff, R., & Bajka, M. (2006). Three-dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging. The Anatomical Record, 288A(1), 84–90. https://doi.org/10.1002/ar.a.20274

Weiss, S. et al. (2006) ‘Three-dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging’, The Anatomical Record, 288A(1), pp. 84–90. Available at: https://doi.org/10.1002/ar.a.20274.

S. Weiss et al., “Three-dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging,” The Anatomical Record, vol. 288A, no. 1, pp. 84–90, 2006, doi: 10.1002/ar.a.20274.

WEISS, Stephan, Thomas JÄRMANN, Peter SCHMID, Philipp STAEMPFLI, Peter BOESIGER, Peter NIEDERER, Rosmarie CADUFF und Michael BAJKA, 2006. Three-dimensional fiber architecture of the nonpregnant human uterus determined ex vivo using magnetic resonance diffusion tensor imaging. The Anatomical Record. 2006. Bd. 288A, Nr. 1, S. 84–90. DOI 10.1002/ar.a.20274

Weiss, Stephan, Thomas Järmann, Peter Schmid, Philipp Staempfli, Peter Boesiger, Peter Niederer, Rosmarie Caduff, and Michael Bajka. 2006. “Three-Dimensional Fiber Architecture of the Nonpregnant Human Uterus Determined Ex Vivo Using Magnetic Resonance Diffusion Tensor Imaging.” The Anatomical Record 288A (1): 84–90. https://doi.org/10.1002/ar.a.20274.

Weiss, Stephan, et al. “Three-Dimensional Fiber Architecture of the Nonpregnant Human Uterus Determined Ex Vivo Using Magnetic Resonance Diffusion Tensor Imaging.” The Anatomical Record, vol. 288A, no. 1, 2006, pp. 84–90, https://doi.org/10.1002/ar.a.20274.