| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema : a 3 T magnetic resonance imaging study |
| Autor/-in: | Schoonman, Guus G Sándor, Peter S Nirkko, Arto C Lange, Thomas Järmann, Thomas Dydak, Ulrike Kremer, Christine Ferrari, Michel D Boesiger, Peter Baumgartner, Ralf W |
| DOI: | 10.1038/sj.jcbfm.9600513 |
| Erschienen in: | Journal of Cerebral Blood Flow & Metabolism |
| Band(Heft): | 28 |
| Heft: | 1 |
| Seite(n): | 198 |
| Seiten bis: | 206 |
| Erscheinungsdatum: | Mai-2007 |
| Verlag / Hrsg. Institution: | Sage |
| ISSN: | 0271-678X 1559-7016 |
| Sprache: | Englisch |
| Schlagwörter: | Acute disease; Adult; Altitude sickness; Brain edema; Cerebrum; Humans; Hypoxia; Male; Radiography; Time factors; Magnetic Resonance Imaging |
| Fachgebiet (DDC): | 616: Innere Medizin und Krankheiten |
| Zusammenfassung: | Acute mountain sickness is common among not acclimatized persons ascending to high altitude; the underlying mechanism is unknown, but may be related to cerebral edema. Nine healthy male students were studied before and after 6-h exposure to isobaric hypoxia. Subjects inhaled room air enriched with N(2) to obtain arterial O(2) saturation values of 75 to 80%. Acute mountain sickness was assessed with the environmental symptom questionnaire, and cerebral edema with 3 T magnetic resonance imaging in 18 regions of interest in the cerebral white matter. The main outcome measures were development of intra- and extracellular cerebral white matter edema assessed by visual inspection and quantitative analysis of apparent diffusion coefficients derived from diffusion-weighted imaging, and B0 signal intensities derived from T2-weighted imaging. Seven of nine subjects developed acute mountain sickness. Mean apparent diffusion coefficient increased 2.12% (baseline, 0.80+/-0.09; 6 h hypoxia, 0.81+/-0.09; P=0.034), and mean B0 signal intensity increased 4.56% (baseline, 432.1+/-98.2; 6 h hypoxia, 450.7+/-102.5; P<0.001). Visual inspection of magnetic resonance images failed to reveal cerebral edema. Cerebral acute mountain sickness scores showed a negative correlation with relative changes of apparent diffusion coefficients (r=-0.83, P=0.006); there was no correlation with relative changes of B0 signal intensities. In conclusion, isobaric hypoxia is associated with mild extracellular (vasogenic) cerebral edema irrespective of the presence of acute mountain sickness in most subjects, and severe acute mountain sickness with additional mild intracellular (cytotoxic) cerebral edema. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/4991 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | School of Engineering |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
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Schoonman, G. G., Sándor, P. S., Nirkko, A. C., Lange, T., Järmann, T., Dydak, U., Kremer, C., Ferrari, M. D., Boesiger, P., & Baumgartner, R. W. (2007). Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema : a 3 T magnetic resonance imaging study. Journal of Cerebral Blood Flow & Metabolism, 28(1), 198–206. https://doi.org/10.1038/sj.jcbfm.9600513
Schoonman, G.G. et al. (2007) ‘Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema : a 3 T magnetic resonance imaging study’, Journal of Cerebral Blood Flow & Metabolism, 28(1), pp. 198–206. Available at: https://doi.org/10.1038/sj.jcbfm.9600513.
G. G. Schoonman et al., “Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema : a 3 T magnetic resonance imaging study,” Journal of Cerebral Blood Flow & Metabolism, vol. 28, no. 1, pp. 198–206, May 2007, doi: 10.1038/sj.jcbfm.9600513.
SCHOONMAN, Guus G, Peter S SÁNDOR, Arto C NIRKKO, Thomas LANGE, Thomas JÄRMANN, Ulrike DYDAK, Christine KREMER, Michel D FERRARI, Peter BOESIGER und Ralf W BAUMGARTNER, 2007. Hypoxia-induced acute mountain sickness is associated with intracellular cerebral edema : a 3 T magnetic resonance imaging study. Journal of Cerebral Blood Flow & Metabolism. Mai 2007. Bd. 28, Nr. 1, S. 198–206. DOI 10.1038/sj.jcbfm.9600513
Schoonman, Guus G, Peter S Sándor, Arto C Nirkko, Thomas Lange, Thomas Järmann, Ulrike Dydak, Christine Kremer, Michel D Ferrari, Peter Boesiger, and Ralf W Baumgartner. 2007. “Hypoxia-Induced Acute Mountain Sickness Is Associated with Intracellular Cerebral Edema : A 3 T Magnetic Resonance Imaging Study.” Journal of Cerebral Blood Flow & Metabolism 28 (1): 198–206. https://doi.org/10.1038/sj.jcbfm.9600513.
Schoonman, Guus G., et al. “Hypoxia-Induced Acute Mountain Sickness Is Associated with Intracellular Cerebral Edema : A 3 T Magnetic Resonance Imaging Study.” Journal of Cerebral Blood Flow & Metabolism, vol. 28, no. 1, May 2007, pp. 198–206, https://doi.org/10.1038/sj.jcbfm.9600513.
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