Immunohistochemistry as a reliable tool for the diagnosis of cystic echinococcosis in patients from Sardinia, Italy : a confirmatory study

Santucciu, Cinzia; Peruzzu, Angela; Fara, Antonella Maria; Cossu, Antonio; Kronenberg, Philipp; Deplazes, Peter; Masala, Giovanna

doi:10.3390/diseases12050084

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-30603

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Immunohistochemistry as a reliable tool for the diagnosis of cystic echinococcosis in patients from Sardinia, Italy : a confirmatory study
Authors:	Santucciu, Cinzia Peruzzu, Angela Fara, Antonella Maria Cossu, Antonio Kronenberg, Philipp Deplazes, Peter Masala, Giovanna
et. al:	No
DOI:	10.3390/diseases12050084 10.21256/zhaw-30603
Published in:	Diseases
Volume(Issue):	12
Issue:	5
Page(s):	84
Issue Date:	2024
Publisher / Ed. Institution:	MDPI
ISSN:	2079-9721
Language:	English
Subjects:	Cystic echinococcosis; Echinococcus granulosus sensu stricto; Echinococcal cyst; Diagnostic tool; Immunohistochemistry; Monoclonal antibody; mAbEm2G11; mAbEmG3
Subject (DDC):	616: Internal medicine and diseases
Abstract:	Cystic Echinococcosis (CE) is a zoonotic disease caused by the larval stage of the tapeworm Echinococcus granulosus sensu lato (s.l.). This study aims to investigate the use of two monoclonal antibodies (mAbEmG3 and mAbEm2G11) by immunohistochemistry (IHC) to confirm the diagnosis of CE in human patients, in particular in those cases in which other techniques fail to provide a correct or conclusive diagnosis. For this purpose, a survey on 13 patients was performed. These subjects were referred to Sardinian hospitals (Italy) from 2017 to 2022 and were suspected to be affected by CE. Our findings from these 13 patients showed the detection of E. granulosus sensu stricto by IHC in 12 of 13 echinococcal cysts, as one sample was of a non-parasitological origin. The results confirmed that IHC, by means of the mAbEmG3 and mAbEm2G11, is a reliable diagnostic tool that showed a very high performances when tested on strain of E. granulosus s.l. from Sardinia.
URI:	https://digitalcollection.zhaw.ch/handle/11475/30603
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Santucciu, C., Peruzzu, A., Fara, A. M., Cossu, A., Kronenberg, P., Deplazes, P., & Masala, G. (2024). Immunohistochemistry as a reliable tool for the diagnosis of cystic echinococcosis in patients from Sardinia, Italy : a confirmatory study. Diseases, 12(5), 84. https://doi.org/10.3390/diseases12050084

Santucciu, C. et al. (2024) ‘Immunohistochemistry as a reliable tool for the diagnosis of cystic echinococcosis in patients from Sardinia, Italy : a confirmatory study’, Diseases, 12(5), p. 84. Available at: https://doi.org/10.3390/diseases12050084.

C. Santucciu et al., “Immunohistochemistry as a reliable tool for the diagnosis of cystic echinococcosis in patients from Sardinia, Italy : a confirmatory study,” Diseases, vol. 12, no. 5, p. 84, 2024, doi: 10.3390/diseases12050084.

SANTUCCIU, Cinzia, Angela PERUZZU, Antonella Maria FARA, Antonio COSSU, Philipp KRONENBERG, Peter DEPLAZES und Giovanna MASALA, 2024. Immunohistochemistry as a reliable tool for the diagnosis of cystic echinococcosis in patients from Sardinia, Italy : a confirmatory study. Diseases. 2024. Bd. 12, Nr. 5, S. 84. DOI 10.3390/diseases12050084

Santucciu, Cinzia, Angela Peruzzu, Antonella Maria Fara, Antonio Cossu, Philipp Kronenberg, Peter Deplazes, and Giovanna Masala. 2024. “Immunohistochemistry as a Reliable Tool for the Diagnosis of Cystic Echinococcosis in Patients from Sardinia, Italy : A Confirmatory Study.” Diseases 12 (5): 84. https://doi.org/10.3390/diseases12050084.

Santucciu, Cinzia, et al. “Immunohistochemistry as a Reliable Tool for the Diagnosis of Cystic Echinococcosis in Patients from Sardinia, Italy : A Confirmatory Study.” Diseases, vol. 12, no. 5, 2024, p. 84, https://doi.org/10.3390/diseases12050084.