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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-29246
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dc.contributor.authorChen, Wenjia-
dc.contributor.authorAnothaisintawee, Thunyarat-
dc.contributor.authorButani, Dimple-
dc.contributor.authorWang, Yi-
dc.contributor.authorZemlyanska, Yaroslava-
dc.contributor.authorWong, Chong Boon Nigel-
dc.contributor.authorVirabhak, Suchin-
dc.contributor.authorHrishikesh, M. A.-
dc.contributor.authorTeerawattananon, Yot-
dc.date.accessioned2023-12-01T15:57:37Z-
dc.date.available2023-12-01T15:57:37Z-
dc.date.issued2022-04-05-
dc.identifier.issn2044-6055de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/29246-
dc.description.abstractIntroduction: Precision medicine (PM) involves gene testing to identify disease risk, enable early diagnosis or guide therapeutic choice, and targeted gene therapy. We aim to perform a systematic review and meta-analysis to quantify the cost-effectiveness profile of PM stratified by intervention type, identify sources of heterogeneity in the value-for-money of PM. Methods and analysis: We will perform a systematic search in Embase, MEDLINE, EconLit and CRD databases for studies published in English language or with translation in English between 1 January 2011 and 8 July 2021 on the topic of cost-effectiveness analysis of PM interventions. The focus will be on studies that reported health and economic outcomes. Study quality will be assessed using the Biases in Economic Studies checklist. The incremental net benefit of PM screening, diagnostic, treatment-targeting and therapeutic interventions over conventional strategies will be respectively pooled across studies using a random-effect model if heterogeneity is present, otherwise a fixed-effect model. Subgroup analyses will be performed based on disease area, WHO region and World Bank country-income level. Additionally, we will identify the potential sources of heterogeneity with random-effect meta-regressions. Finally, biases will be detected using jackknife sensitivity analysis, funnel plot assessment and Egger’s tests. Ethics and dissemination: For this type of study ethics approval or formal consent is not required. The results will be disseminated at various presentations and feedback sessions, in conference abstracts and manuscripts that will be submitted to peer-reviewed journals.de_CH
dc.language.isoende_CH
dc.publisherBMJ Publishing Groupde_CH
dc.relation.ispartofBMJ Opende_CH
dc.rightshttps://creativecommons.org/licenses/by-nc/4.0/de_CH
dc.subjectGeneticsde_CH
dc.subjectHealth economicsde_CH
dc.subjectPublic healthde_CH
dc.subjectCost-benefit analysisde_CH
dc.subject.ddc362.1041: Gesundheitsökonomiede_CH
dc.titleAssessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysisde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Management and Lawde_CH
zhaw.organisationalunitWinterthurer Institut für Gesundheitsökonomie (WIG)de_CH
dc.identifier.doi10.1136/bmjopen-2021-057537de_CH
dc.identifier.doi10.21256/zhaw-29246-
dc.identifier.pmid35383079de_CH
zhaw.funding.euNode_CH
zhaw.issue4de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.starte057537de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume12de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Chen, W., Anothaisintawee, T., Butani, D., Wang, Y., Zemlyanska, Y., Wong, C. B. N., Virabhak, S., Hrishikesh, M. A., & Teerawattananon, Y. (2022). Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis. BMJ Open, 12(4), e057537. https://doi.org/10.1136/bmjopen-2021-057537
Chen, W. et al. (2022) ‘Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis’, BMJ Open, 12(4), p. e057537. Available at: https://doi.org/10.1136/bmjopen-2021-057537.
W. Chen et al., “Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis,” BMJ Open, vol. 12, no. 4, p. e057537, Apr. 2022, doi: 10.1136/bmjopen-2021-057537.
CHEN, Wenjia, Thunyarat ANOTHAISINTAWEE, Dimple BUTANI, Yi WANG, Yaroslava ZEMLYANSKA, Chong Boon Nigel WONG, Suchin VIRABHAK, M. A. HRISHIKESH und Yot TEERAWATTANANON, 2022. Assessing the cost-effectiveness of precision medicine : protocol for a systematic review and meta-analysis. BMJ Open. 5 April 2022. Bd. 12, Nr. 4, S. e057537. DOI 10.1136/bmjopen-2021-057537
Chen, Wenjia, Thunyarat Anothaisintawee, Dimple Butani, Yi Wang, Yaroslava Zemlyanska, Chong Boon Nigel Wong, Suchin Virabhak, M. A. Hrishikesh, and Yot Teerawattananon. 2022. “Assessing the Cost-Effectiveness of Precision Medicine : Protocol for a Systematic Review and Meta-Analysis.” BMJ Open 12 (4): e057537. https://doi.org/10.1136/bmjopen-2021-057537.
Chen, Wenjia, et al. “Assessing the Cost-Effectiveness of Precision Medicine : Protocol for a Systematic Review and Meta-Analysis.” BMJ Open, vol. 12, no. 4, Apr. 2022, p. e057537, https://doi.org/10.1136/bmjopen-2021-057537.


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