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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26823
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dc.contributor.authorBagatella, Stefano-
dc.contributor.authorHaghayegh Jahromi, Neda-
dc.contributor.authorMonney, Camille-
dc.contributor.authorPolidori, Margherita-
dc.contributor.authorGall, Flavio Max-
dc.contributor.authorMarchionatti, Emma-
dc.contributor.authorSerra, Fabienne-
dc.contributor.authorRiedl, Rainer-
dc.contributor.authorEngelhardt, Britta-
dc.contributor.authorOevermann, Anna-
dc.date.accessioned2023-02-09T10:18:07Z-
dc.date.available2023-02-09T10:18:07Z-
dc.date.issued2022-12-16-
dc.identifier.issn1742-2094de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26823-
dc.description.abstractBackground: Listeria monocytogenes (Lm) is a bacterial pathogen of major concern for humans and ruminants due to its neuroinvasive potential and its ability to cause deadly encephalitis (neurolisteriosis). On one hand, polymorphonuclear neutrophils (PMN) are key players in the defense against Lm, but on the other hand intracerebral infiltration with PMN is associated with significant neural tissue damage. Lm-PMN interactions in neurolisteriosis are poorly investigated, and factors inducing PMN chemotaxis to infectious foci containing Lm in the central nervous system (CNS) remain unidentified. Methods: In this study, we assessed bovine PMN chemotaxis towards Lm and supernatants of infected endogenous brain cell populations in ex vivo chemotaxis assays, to identify chemotactic stimuli for PMN chemotaxis towards Lm in the brain. In addition, microglial secretion of IL-8 was assessed both ex vivo and in situ. Results: Our data show that neither Lm cell wall components nor intact bacteria elicit chemotaxis of bovine PMN ex vivo. Moreover, astrocytes and neural cells fail to induce bovine PMN chemotaxis upon infection. In contrast, supernatant from Lm infected microglia readily induced chemotaxis of bovine PMN. Microglial expression and secretion of IL-8 was identified during early Lm infection in vitro and in situ, although IL-8 blocking with a specific antibody could not abrogate PMN chemotaxis towards Lm infected microglial supernatant. Conclusions: These data provide evidence that host-derived rather than bacterial factors trigger PMN chemotaxis to bacterial foci in the CNS, that microglia have a primary role as initiators of bovine PMN chemotaxis into the brain during neurolisteriosis and that blockade of these factors could be a therapeutic target to limit intrathecal PMN chemotaxis and PMN associated damage in neurolisteriosis.de_CH
dc.language.isoende_CH
dc.publisherBioMed Centralde_CH
dc.relation.ispartofJournal of Neuroinflammationde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectFormyl peptidede_CH
dc.subjectIL-8de_CH
dc.subjectMicrogliade_CH
dc.subjectNeuroinfectionde_CH
dc.subjectNeurolisteriosisde_CH
dc.subjectNeutrophilde_CH
dc.subjectHumande_CH
dc.subjectMicrogliade_CH
dc.subjectChemotaxisde_CH
dc.subjectInterleukin-8de_CH
dc.subjectChemotaxis, leukocytede_CH
dc.subjectListeria monocytogenede_CH
dc.subject.ddc579: Mikrobiologiede_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.titleBovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factorsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1186/s12974-022-02653-1de_CH
dc.identifier.doi10.21256/zhaw-26823-
dc.identifier.pmid36527076de_CH
zhaw.funding.euNode_CH
zhaw.issue304de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume19de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.funding.snf197879de_CH
zhaw.webfeedOrganische Chemiede_CH
zhaw.webfeedCC Drug Discoveryde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Bagatella, S., Haghayegh Jahromi, N., Monney, C., Polidori, M., Gall, F. M., Marchionatti, E., Serra, F., Riedl, R., Engelhardt, B., & Oevermann, A. (2022). Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors. Journal of Neuroinflammation, 19(304). https://doi.org/10.1186/s12974-022-02653-1
Bagatella, S. et al. (2022) ‘Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors’, Journal of Neuroinflammation, 19(304). Available at: https://doi.org/10.1186/s12974-022-02653-1.
S. Bagatella et al., “Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors,” Journal of Neuroinflammation, vol. 19, no. 304, Dec. 2022, doi: 10.1186/s12974-022-02653-1.
BAGATELLA, Stefano, Neda HAGHAYEGH JAHROMI, Camille MONNEY, Margherita POLIDORI, Flavio Max GALL, Emma MARCHIONATTI, Fabienne SERRA, Rainer RIEDL, Britta ENGELHARDT und Anna OEVERMANN, 2022. Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors. Journal of Neuroinflammation. 16 Dezember 2022. Bd. 19, Nr. 304. DOI 10.1186/s12974-022-02653-1
Bagatella, Stefano, Neda Haghayegh Jahromi, Camille Monney, Margherita Polidori, Flavio Max Gall, Emma Marchionatti, Fabienne Serra, Rainer Riedl, Britta Engelhardt, and Anna Oevermann. 2022. “Bovine Neutrophil Chemotaxis to Listeria Monocytogenes in Neurolisteriosis Depends on Microglia-Released rather than Bacterial Factors.” Journal of Neuroinflammation 19 (304). https://doi.org/10.1186/s12974-022-02653-1.
Bagatella, Stefano, et al. “Bovine Neutrophil Chemotaxis to Listeria Monocytogenes in Neurolisteriosis Depends on Microglia-Released rather than Bacterial Factors.” Journal of Neuroinflammation, vol. 19, no. 304, Dec. 2022, https://doi.org/10.1186/s12974-022-02653-1.


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