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  4. Publikationen Angewandte Psychologie
Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-23838
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dc.contributor.authorPlöderl, Martin-
dc.contributor.authorHengartner, Michael Pascal-
dc.date.accessioned2022-01-07T11:33:42Z-
dc.date.available2022-01-07T11:33:42Z-
dc.date.issued2021-12-17-
dc.identifier.issn0227-5910de_CH
dc.identifier.issn2151-2396de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/23838-
dc.description.abstractBackground: Some authors claimed that the US Food and Drug Administration (FDA) black box warning on treatment-emergent suicidality with antidepressants in adolescents (issued 2004) and young adults (issued 2006) led to an increase of suicides, based on the analyses of ecological data with debatable assumptions about putative changes in suicide rates. Aims: To explore if putative changes in suicide rates in adolescents and young adults at the time of the FDA warnings is a detectable signal in the data or compatible with random fluctuations. Method: We applied different changepoint analyses for adolescent and young adult suicide rates from 1981 to 2019 in the USA. Results: Changepoint analysis did not support a detrimental effect of the FDA black box warnings. The downward trend of suicides reversed several years after the warning in adolescents (2007–2009) and many years before in young adults (1999–2001). Limitations: Our analyses cannot rule out detrimental effects of the FDA warnings. However, even if there was such an effect, it was likely small and indistinguishable from random fluctuations in the available suicide data. Conclusion: There is no detectable change of trend in adolescent or young adult suicide rates in line with a detrimental effect of the FDA black box warnings on treatment-emergent suicidality.de_CH
dc.language.isoende_CH
dc.publisherHogrefede_CH
dc.relation.ispartofCrisisde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectSuicidede_CH
dc.subjectAntidepressantsde_CH
dc.subjectFDAde_CH
dc.subjectBlack box warningde_CH
dc.subjectAdolescentsde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.subject.ddc616.8: Neurologie und Krankheiten des Nervensystemsde_CH
dc.titleEffect of the FDA black box suicidality warnings for antidepressants on suicide rates in the USA : signal or noise?de_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementAngewandte Psychologiede_CH
zhaw.organisationalunitPsychologisches Institut (PI)de_CH
dc.identifier.doi10.1027/0227-5910/a000843de_CH
dc.identifier.doi10.21256/zhaw-23838-
zhaw.funding.euNode_CH
zhaw.issue2de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end134de_CH
zhaw.pages.start128de_CH
zhaw.publication.statusacceptedVersionde_CH
zhaw.volume44de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedKlinische Psychologiede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Plöderl, M., & Hengartner, M. P. (2021). Effect of the FDA black box suicidality warnings for antidepressants on suicide rates in the USA : signal or noise? Crisis, 44(2), 128–134. https://doi.org/10.1027/0227-5910/a000843
Plöderl, M. and Hengartner, M.P. (2021) ‘Effect of the FDA black box suicidality warnings for antidepressants on suicide rates in the USA : signal or noise?’, Crisis, 44(2), pp. 128–134. Available at: https://doi.org/10.1027/0227-5910/a000843.
M. Plöderl and M. P. Hengartner, “Effect of the FDA black box suicidality warnings for antidepressants on suicide rates in the USA : signal or noise?,” Crisis, vol. 44, no. 2, pp. 128–134, Dec. 2021, doi: 10.1027/0227-5910/a000843.
PLÖDERL, Martin und Michael Pascal HENGARTNER, 2021. Effect of the FDA black box suicidality warnings for antidepressants on suicide rates in the USA : signal or noise? Crisis. 17 Dezember 2021. Bd. 44, Nr. 2, S. 128–134. DOI 10.1027/0227-5910/a000843
Plöderl, Martin, and Michael Pascal Hengartner. 2021. “Effect of the FDA Black Box Suicidality Warnings for Antidepressants on Suicide Rates in the USA : Signal or Noise?” Crisis 44 (2): 128–34. https://doi.org/10.1027/0227-5910/a000843.
Plöderl, Martin, and Michael Pascal Hengartner. “Effect of the FDA Black Box Suicidality Warnings for Antidepressants on Suicide Rates in the USA : Signal or Noise?” Crisis, vol. 44, no. 2, Dec. 2021, pp. 128–34, https://doi.org/10.1027/0227-5910/a000843.


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