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https://doi.org/10.21256/zhaw-23775| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem |
| Autor/-in: | Scheidegger, Stephan Mingo Barba, Sergio Gaipl, Udo S. |
| et. al: | No |
| DOI: | 10.3390/cancers13225764 10.21256/zhaw-23775 |
| Erschienen in: | Cancers |
| Band(Heft): | 13 |
| Heft: | 22 |
| Seite(n): | 5764 |
| Erscheinungsdatum: | 17-Nov-2021 |
| Verlag / Hrsg. Institution: | MDPI |
| ISSN: | 2072-6694 |
| Sprache: | Englisch |
| Schlagwörter: | Antigen pattern; Danger signal; Fractionation; Immune response; Immune system in silico; Perceptron; Systems medicine |
| Fachgebiet (DDC): | 616: Innere Medizin und Krankheiten |
| Zusammenfassung: | There is some evidence that radiotherapy (RT) can trigger anti-tumor immune responses. In addition, hyperthermia (HT) is known to be a tumor cell radio-sensitizer. How HT could enhance the anti-tumor immune response produced by RT is still an open question. The aim of this study is the evaluation of potential dynamic effects regarding the adaptive immune response induced by different combinations of RT fractions with HT. The adaptive immune system is considered as a trainable unit (perceptron) which compares danger signals released by necrotic or apoptotic cell death with the presence of tumor- and host tissue cell population-specific molecular patterns (antigens). To mimic the changes produced by HT such as cell radio-sensitization or increase of the blood perfusion after hyperthermia, simplistic biophysical models were included. To study the effectiveness of the different RT+HT treatments, the Tumor Control Probability (TCP) was calculated. In the considered scenarios, the major effect of HT is related to the enhancement of the cell radio-sensitivity while perfusion or heat-based effects on the immune system seem to contribute less. Moreover, no tumor vaccination effect has been observed. In the presented scenarios, HT boosts the RT cell killing but it does not fundamentally change the anti-tumor immune response. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/23775 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | School of Engineering |
| Organisationseinheit: | Institut für Angewandte Mathematik und Physik (IAMP) |
| Publiziert im Rahmen des ZHAW-Projekts: | Hyperboost |
| Enthalten in den Sammlungen: | Publikationen School of Engineering |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2021_Scheidegger-etal_HT-RT-in-artificial-immune-tumor-ecosystem.pdf | 1.77 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Scheidegger, S., Mingo Barba, S., & Gaipl, U. S. (2021). Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem. Cancers, 13(22), 5764. https://doi.org/10.3390/cancers13225764
Scheidegger, S., Mingo Barba, S. and Gaipl, U.S. (2021) ‘Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem’, Cancers, 13(22), p. 5764. Available at: https://doi.org/10.3390/cancers13225764.
S. Scheidegger, S. Mingo Barba, and U. S. Gaipl, “Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem,” Cancers, vol. 13, no. 22, p. 5764, Nov. 2021, doi: 10.3390/cancers13225764.
SCHEIDEGGER, Stephan, Sergio MINGO BARBA und Udo S. GAIPL, 2021. Theoretical evaluation of the impact of hyperthermia in combination with radiation therapy in an artificial immune-tumor-ecosystem. Cancers. 17 November 2021. Bd. 13, Nr. 22, S. 5764. DOI 10.3390/cancers13225764
Scheidegger, Stephan, Sergio Mingo Barba, and Udo S. Gaipl. 2021. “Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune-Tumor-Ecosystem.” Cancers 13 (22): 5764. https://doi.org/10.3390/cancers13225764.
Scheidegger, Stephan, et al. “Theoretical Evaluation of the Impact of Hyperthermia in Combination with Radiation Therapy in an Artificial Immune-Tumor-Ecosystem.” Cancers, vol. 13, no. 22, Nov. 2021, p. 5764, https://doi.org/10.3390/cancers13225764.
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