Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder : a protocol for a systematic review with meta-analysis and Trial Sequential Analysis

Jørgensen, Caroline Kamp; Juul, Sophie; Siddiqui, Faiza; Barbateskovic, Marija; Munkholm, Klaus; Hengartner, Michael Pascal; Kirsch, Irving; Gluud, Christian; Jakobsen, Janus Christian

doi:10.1186/s13643-021-01789-0

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-22972

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder : a protocol for a systematic review with meta-analysis and Trial Sequential Analysis
Authors:	Jørgensen, Caroline Kamp Juul, Sophie Siddiqui, Faiza Barbateskovic, Marija Munkholm, Klaus Hengartner, Michael Pascal Kirsch, Irving Gluud, Christian Jakobsen, Janus Christian
et. al:	No
DOI:	10.1186/s13643-021-01789-0 10.21256/zhaw-22972
Published in:	Systematic Reviews
Volume(Issue):	10
Issue:	227
Issue Date:	2021
Publisher / Ed. Institution:	BioMed Central
ISSN:	2046-4053
Language:	English
Subject (DDC):	615: Pharmacology and therapeutics 616.8: Neurology, diseases of nervous system
Abstract:	Background: Major depressive disorder is a common psychiatric disorder causing great burden on patients and societies. Tricyclic antidepressants are frequently used worldwide to treat patients with major depressive disorder. It has repeatedly been shown that tricyclic antidepressants reduce depressive symptoms with a statistically significant effect, but the effect is small and of questionable clinical importance. Moreover, the beneficial and harmful effects of all types of tricyclic antidepressants have not previously been systematically assessed. Therefore, we aim to investigate the beneficial and harmful effects of tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder. Methods: This is a protocol for a systematic review with meta-analysis that will be reported as recommended by Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols, bias will be assessed with the Cochrane Risk of Bias tool—version 2, our eight-step procedure will be used to assess if the thresholds for clinical significance are crossed, Trial Sequential Analysis will be conducted to control random errors and the certainty of the evidence will be assessed with the Grading of Recommendations Assessment, Development and Evaluation approach. To identify relevant trials, we will search both for published and unpublished trials in major medical databases and trial registers, such as CENTRAL, MEDLINE, EMBASE and ClinicalTrials.gov from their inception to 12 May 2021. Clinical study reports will be applied for from regulatory authorities and pharmaceutical companies. Two review authors will independently screen the results from the literature searches, extract data and perform risk of bias assessment. We will include any published or unpublished randomised clinical trial comparing tricyclic antidepressants with ‘active placebo’, placebo or no intervention for adults with major depressive disorder. The following interventions will be assessed: amineptine, amitriptyline, amoxapine, butriptyline, cianopramine, clomipramine, desipramine, demexiptiline, dibenzepin, dosulepin, dothiepin, doxepin, imipramine, iprindole, lofepramine, maprotiline, melitracen, metapramine, nortriptyline, noxiptiline, opipramol, protriptyline, tianeptine, trimipramine and quinupramine. Primary outcomes will be depressive symptoms, serious adverse events and quality of life. Secondary outcomes will be suicide or suicide-attempts and non-serious adverse events. If feasible, we will assess the intervention effects using random-effects and fixed-effect meta-analyses. Discussion: Tricyclic antidepressants are recommended by clinical guidelines and frequently used worldwide in the treatment of major depressive disorder. There is a need for a thorough systematic review to provide the necessary background for weighing the benefits against the harms. This review will ultimately inform best practice in the treatment of major depressive disorder.
URI:	https://digitalcollection.zhaw.ch/handle/11475/22972
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	Publikationen Angewandte Psychologie

Files in This Item:

File	Description	Size	Format
2021_Jorgensen-etal_Tricyclic-antidepressants-versus-active-placebo.pdf		1.06 MB	Adobe PDF	View/Open

Show full item record

Jørgensen, C. K., Juul, S., Siddiqui, F., Barbateskovic, M., Munkholm, K., Hengartner, M. P., Kirsch, I., Gluud, C., & Jakobsen, J. C. (2021). Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder : a protocol for a systematic review with meta-analysis and Trial Sequential Analysis. Systematic Reviews, 10(227). https://doi.org/10.1186/s13643-021-01789-0

Jørgensen, C.K. et al. (2021) ‘Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder : a protocol for a systematic review with meta-analysis and Trial Sequential Analysis’, Systematic Reviews, 10(227). Available at: https://doi.org/10.1186/s13643-021-01789-0.

C. K. Jørgensen et al., “Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder : a protocol for a systematic review with meta-analysis and Trial Sequential Analysis,” Systematic Reviews, vol. 10, no. 227, 2021, doi: 10.1186/s13643-021-01789-0.

JØRGENSEN, Caroline Kamp, Sophie JUUL, Faiza SIDDIQUI, Marija BARBATESKOVIC, Klaus MUNKHOLM, Michael Pascal HENGARTNER, Irving KIRSCH, Christian GLUUD und Janus Christian JAKOBSEN, 2021. Tricyclic antidepressants versus ‘active placebo’, placebo or no intervention for adults with major depressive disorder : a protocol for a systematic review with meta-analysis and Trial Sequential Analysis. Systematic Reviews. 2021. Bd. 10, Nr. 227. DOI 10.1186/s13643-021-01789-0

Jørgensen, Caroline Kamp, Sophie Juul, Faiza Siddiqui, Marija Barbateskovic, Klaus Munkholm, Michael Pascal Hengartner, Irving Kirsch, Christian Gluud, and Janus Christian Jakobsen. 2021. “Tricyclic Antidepressants versus ‘Active Placebo’, Placebo or No Intervention for Adults with Major Depressive Disorder : A Protocol for a Systematic Review with Meta-Analysis and Trial Sequential Analysis.” Systematic Reviews 10 (227). https://doi.org/10.1186/s13643-021-01789-0.

Jørgensen, Caroline Kamp, et al. “Tricyclic Antidepressants versus ‘Active Placebo’, Placebo or No Intervention for Adults with Major Depressive Disorder : A Protocol for a Systematic Review with Meta-Analysis and Trial Sequential Analysis.” Systematic Reviews, vol. 10, no. 227, 2021, https://doi.org/10.1186/s13643-021-01789-0.