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  4. Publikationen Life Sciences und Facility Management
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dc.contributor.authorTrifan, A-
dc.contributor.authorLuca, SV-
dc.contributor.authorWolfram, Evelyn-
dc.contributor.authorVasincu, A-
dc.contributor.authorOpitz, EWS-
dc.contributor.authorAprotosoaie, AC-
dc.contributor.authorMiron, A-
dc.contributor.authorJitareanu, A-
dc.contributor.authorNeophytou, C-
dc.contributor.authorConstantinou, IA-
dc.date.accessioned2020-10-29T12:57:43Z-
dc.date.available2020-10-29T12:57:43Z-
dc.date.issued2019-12-20-
dc.identifier.issn0032-0943de_CH
dc.identifier.issn1439-0221de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/20711-
dc.description.abstractThe Romanian Black Sea has abundant seaweed resources, but little effort has been done to screen their biological potential. The aim of the present study was to assess the in vitro antioxidant and antiproliferative activities of Cystoseira barbata Sargassaceae a brown alga inhbiting the costal line of Romanian Black Sea. 70% acetone, methanol and water were used for the extraction of the algal material. The antioxidant activity of C. barbata extracts was assessed by DPPH and ABTS radicals scavenging assays, reducing power and 15-lipoxygenase inhibition assays. Cytotoxic activity of the extracts was determined by MTT viability assay using three adenocarcinoma cell lines (mammary MCF-7, alveolar A549 and colorectal HT-29). The effect of the extracts in cell cycle distribution was evaluated using flow cytometry (FACS) [1],[2]. 70% acetone extract exhibited the highest antioxidant activities in all assays, with IC50 values comparable or higher than those of known antioxidants. The antitumor tests showed that 70% acetone extract had the most potent antiproliferative effects. MCF-7 was the most sensitive of all cell lines examined. FACS analysis revealed that the 70% acetone extract induced a significant increase in the subG1 fraction in MCF-7 and A549 cells, indicative of apoptosis induction. From these findings, the 70% acetone extract was investigated by HPLC-DAD-QTOF-ESI-MS/MS [3]; phlorotannins with molecular weights ranging from 375 to 870 Da were tentatively identified on the basis of their characteristic MS/MS fragmentation pattern. In conclusion, Cystoseira barbata represents an important source of bioactive compounds, with potential use in food and pharmaceutical industries.de_CH
dc.language.isoende_CH
dc.publisherThiemede_CH
dc.relation.ispartofPlanta Medicade_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAlgaede_CH
dc.subjectPhlorotanninsde_CH
dc.subjectCystoseita barbatade_CH
dc.subjectLC-MSde_CH
dc.subject.ddc570: Biologiede_CH
dc.subject.ddc610: Medizin und Gesundheitde_CH
dc.titleCystoseira barbata C. Agardh from Romanian Black Sea coast : phlorotannins profile, in vitro antioxidant and antiproliferative potentialde_CH
dc.typeKonferenz: Posterde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publisher.placeStuttgartde_CH
dc.identifier.doi10.1055/s-0039-3400023de_CH
zhaw.conference.details67th Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA), Innsbruck, Austria, 1-5 September 2019de_CH
zhaw.funding.euNode_CH
zhaw.issue18de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end1525de_CH
zhaw.pages.start1524de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume85de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPhytopharmaziede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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Trifan, A., Luca, S., Wolfram, E., Vasincu, A., Opitz, E., Aprotosoaie, A., Miron, A., Jitareanu, A., Neophytou, C., & Constantinou, I. (2019). Cystoseira barbata C. Agardh from Romanian Black Sea coast : phlorotannins profile, in vitro antioxidant and antiproliferative potential [Conference poster]. Planta Medica, 85(18), 1524–1525. https://doi.org/10.1055/s-0039-3400023
Trifan, A. et al. (2019) ‘Cystoseira barbata C. Agardh from Romanian Black Sea coast : phlorotannins profile, in vitro antioxidant and antiproliferative potential’, in Planta Medica. Stuttgart: Thieme, pp. 1524–1525. Available at: https://doi.org/10.1055/s-0039-3400023.
A. Trifan et al., “Cystoseira barbata C. Agardh from Romanian Black Sea coast : phlorotannins profile, in vitro antioxidant and antiproliferative potential,” in Planta Medica, Dec. 2019, vol. 85, no. 18, pp. 1524–1525. doi: 10.1055/s-0039-3400023.
TRIFAN, A, SV LUCA, Evelyn WOLFRAM, A VASINCU, EWS OPITZ, AC APROTOSOAIE, A MIRON, A JITAREANU, C NEOPHYTOU und IA CONSTANTINOU, 2019. Cystoseira barbata C. Agardh from Romanian Black Sea coast : phlorotannins profile, in vitro antioxidant and antiproliferative potential. In: Planta Medica. Conference poster. Stuttgart: Thieme. 20 Dezember 2019. S. 1524–1525
Trifan, A, SV Luca, Evelyn Wolfram, A Vasincu, EWS Opitz, AC Aprotosoaie, A Miron, A Jitareanu, C Neophytou, and IA Constantinou. 2019. “Cystoseira Barbata C. Agardh from Romanian Black Sea Coast : Phlorotannins Profile, in Vitro Antioxidant and Antiproliferative Potential.” Conference poster. In Planta Medica, 85:1524–25. Stuttgart: Thieme. https://doi.org/10.1055/s-0039-3400023.
Trifan, A., et al. “Cystoseira Barbata C. Agardh from Romanian Black Sea Coast : Phlorotannins Profile, in Vitro Antioxidant and Antiproliferative Potential.” Planta Medica, vol. 85, no. 18, Thieme, 2019, pp. 1524–25, https://doi.org/10.1055/s-0039-3400023.


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