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https://doi.org/10.21256/zhaw-19348| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Is atopic sensitization associated with indicators of early vascular ageing in adolescents? |
| Autor/-in: | Königstein, Karsten Infanger, Denis Jacobsen Bertelsen, Randi Johannessen, Ane Waje-Andreassen, Ulrike Schmidt-Trucksäss, Arno Svanes, Cecilie Dratva, Julia |
| et. al: | No |
| DOI: | 10.1371/journal.pone.0220198 10.21256/zhaw-19348 |
| Erschienen in: | PLOS ONE |
| Band(Heft): | 14 |
| Heft: | 8 |
| Seite(n): | e0220198 |
| Erscheinungsdatum: | 2019 |
| Verlag / Hrsg. Institution: | Public Library of Science |
| ISSN: | 1932-6203 |
| Sprache: | Englisch |
| Fachgebiet (DDC): | 616: Innere Medizin und Krankheiten |
| Zusammenfassung: | Background Chronic systemic inflammation accelerates early vascular ageing. Atopic sensitization and allergic diseases may involve increased inflammatory activity. This study aimed to assess whether atopic sensitization and allergic diseases were associated with altered vascular biomarkers in Norwegian adolescents. Methods Distensibility coefficient of the common carotid arteries, carotid intima-media thickness and atopic sensitization (serum total and specific IgEs) were assessed in 95 Norwegian adolescents, who participated in the RHINESSA generation study. Symptoms of allergic disease were assessed by an interviewer-led questionnaire. Results Atopic sensitization was found in 33 (34.7%) of the adolescents. Symptomatic allergic disease was found in 11 (33.3%) of those with atopic sensitization. Distensibility coefficient of the common carotid arteries appeared to be lower in participants with atopic sensitization than in those without (46.99±8.07*10−3/kPa versus 51.50±11.46*10−3/kPa; p>0.05), while carotid intima-media thickness did not differ between these groups (0.50±0.04mm versus 0.50±0.04mm; p>0.05). Crude, as well as age- and sex-adjusted multiple regression, revealed no significant association, neither of atopic sensitization nor of allergic disease, with distensibility coefficient of the common carotid arteries and carotid intima-media thickness. Conclusions Our results do not support the assumption of an adverse impact of atopic sensitization and/or allergic disease on distensibility coefficient of the common carotid arteries and carotid intima-media thickness in Norwegian adolescents. Further research is necessary to study whether the clinical severity of allergic diseases might be more important than the status of allergic disease or atopic sensitization. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/19348 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | CC BY 4.0: Namensnennung 4.0 International |
| Departement: | Gesundheit |
| Organisationseinheit: | Institut für Public Health (IPH) |
| Enthalten in den Sammlungen: | Publikationen Gesundheit |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2019Königstein-etal_journal.pone.0220198.pdf | 593.77 kB | Adobe PDF |  Öffnen/Anzeigen |
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Königstein, K., Infanger, D., Jacobsen Bertelsen, R., Johannessen, A., Waje-Andreassen, U., Schmidt-Trucksäss, A., Svanes, C., & Dratva, J. (2019). Is atopic sensitization associated with indicators of early vascular ageing in adolescents? Plos One, 14(8), e0220198. https://doi.org/10.1371/journal.pone.0220198
Königstein, K. et al. (2019) ‘Is atopic sensitization associated with indicators of early vascular ageing in adolescents?’, PLOS ONE, 14(8), p. e0220198. Available at: https://doi.org/10.1371/journal.pone.0220198.
K. Königstein et al., “Is atopic sensitization associated with indicators of early vascular ageing in adolescents?,” PLOS ONE, vol. 14, no. 8, p. e0220198, 2019, doi: 10.1371/journal.pone.0220198.
KÖNIGSTEIN, Karsten, Denis INFANGER, Randi JACOBSEN BERTELSEN, Ane JOHANNESSEN, Ulrike WAJE-ANDREASSEN, Arno SCHMIDT-TRUCKSÄSS, Cecilie SVANES und Julia DRATVA, 2019. Is atopic sensitization associated with indicators of early vascular ageing in adolescents? PLOS ONE. 2019. Bd. 14, Nr. 8, S. e0220198. DOI 10.1371/journal.pone.0220198
Königstein, Karsten, Denis Infanger, Randi Jacobsen Bertelsen, Ane Johannessen, Ulrike Waje-Andreassen, Arno Schmidt-Trucksäss, Cecilie Svanes, and Julia Dratva. 2019. “Is Atopic Sensitization Associated with Indicators of Early Vascular Ageing in Adolescents?” Plos One 14 (8): e0220198. https://doi.org/10.1371/journal.pone.0220198.
Königstein, Karsten, et al. “Is Atopic Sensitization Associated with Indicators of Early Vascular Ageing in Adolescents?” Plos One, vol. 14, no. 8, 2019, p. e0220198, https://doi.org/10.1371/journal.pone.0220198.
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