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  4. Publikationen School of Management and Law
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dc.contributor.authorObeid, Rima-
dc.contributor.authorPietrzik, Klaus-
dc.contributor.authorOakley, Godfrey-
dc.contributor.authorKancherla, Vijaya-
dc.contributor.authorHolzgreve, Wolfgang-
dc.contributor.authorWieser, Simon-
dc.date.accessioned2018-11-15T14:23:27Z-
dc.date.available2018-11-15T14:23:27Z-
dc.date.issued2015-
dc.identifier.issn1542-0752de_CH
dc.identifier.issn1542-0760de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/12834-
dc.description.abstractBackground: Promotion of voluntary folic acid supplement use among women of reproductive age has been proven to be ineffective in lowering the risk of neural tube defects in Europe. Methods: Using surveillance data from all births covered by the full member countries of the European Surveillance of Congenital Anomalies (EUROCAT), we estimated the total prevalence of spina bifida and anencephaly per 10,000 births between 2000 and 2010. We also estimated additional lifetime direct medical costs among individuals with spina bifida, compared with those without, in Germany for the year 2009. Results: During the study period, there were 7478 documented cases of spina bifida and anencephaly among the 9,161,189 births, with an estimated average combined prevalence of 8.16 per 10,000 births (95% confidence interval, 7.98 - 8.35). For the 241 spina bifida-affected live births in 2009 in Germany, the estimated additional lifetime direct medical costs compared with non-spina bifida affected births were €65.5 million. Assuming a 50% reduction in the prevalence if folic acid has been provided to all women before pregnancy, 293 spina bifida cases could have been prevented in Germany in 2009. The estimated lifetime direct medical cost saving for the live births in 2009 was €32.9 million assuming a 50% reduction, or €26.1 million assuming a 40% risk reduction. Conclusion: Europe has an epidemic of spina bifida and anencephaly compared with countries with mandatory folic acid fortification policy. Primary prevention through mandatory folic acid fortification would considerably reduce the number of affected pregnancies, and associated additional costs.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofBirth Defects Researchde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAnencephalyde_CH
dc.subjectEconomicde_CH
dc.subjectFolic acidde_CH
dc.subjectFortificationde_CH
dc.subjectNeural tube defectsde_CH
dc.subjectPregnancyde_CH
dc.subjectPreventionde_CH
dc.subjectSpina bifidade_CH
dc.subjectAnencephalyde_CH
dc.subjectDietary Supplementsde_CH
dc.subjectEthnic Groupsde_CH
dc.subjectEuropede_CH
dc.subjectEuropean Continental Ancestry Groupde_CH
dc.subjectFemalede_CH
dc.subjectFolic Acidde_CH
dc.subjectFood, Fortifiedde_CH
dc.subjectHumansde_CH
dc.subjectLive Birthde_CH
dc.subjectPregnancyde_CH
dc.subjectPrevalencede_CH
dc.subjectSpinal Dysraphismde_CH
dc.subject.ddc616.7: Krankheiten des Bewegungsapparates und Orthopädiede_CH
dc.titlePreventable spina bifida and anencephaly in Europede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Management and Lawde_CH
zhaw.organisationalunitWinterthurer Institut für Gesundheitsökonomie (WIG)de_CH
dc.identifier.doi10.1002/bdra.23400de_CH
dc.identifier.pmid26178749de_CH
zhaw.funding.euNode_CH
zhaw.issue9de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end771de_CH
zhaw.pages.start763de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume103de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Obeid, R., Pietrzik, K., Oakley, G., Kancherla, V., Holzgreve, W., & Wieser, S. (2015). Preventable spina bifida and anencephaly in Europe. Birth Defects Research, 103(9), 763–771. https://doi.org/10.1002/bdra.23400
Obeid, R. et al. (2015) ‘Preventable spina bifida and anencephaly in Europe’, Birth Defects Research, 103(9), pp. 763–771. Available at: https://doi.org/10.1002/bdra.23400.
R. Obeid, K. Pietrzik, G. Oakley, V. Kancherla, W. Holzgreve, and S. Wieser, “Preventable spina bifida and anencephaly in Europe,” Birth Defects Research, vol. 103, no. 9, pp. 763–771, 2015, doi: 10.1002/bdra.23400.
OBEID, Rima, Klaus PIETRZIK, Godfrey OAKLEY, Vijaya KANCHERLA, Wolfgang HOLZGREVE und Simon WIESER, 2015. Preventable spina bifida and anencephaly in Europe. Birth Defects Research. 2015. Bd. 103, Nr. 9, S. 763–771. DOI 10.1002/bdra.23400
Obeid, Rima, Klaus Pietrzik, Godfrey Oakley, Vijaya Kancherla, Wolfgang Holzgreve, and Simon Wieser. 2015. “Preventable Spina Bifida and Anencephaly in Europe.” Birth Defects Research 103 (9): 763–71. https://doi.org/10.1002/bdra.23400.
Obeid, Rima, et al. “Preventable Spina Bifida and Anencephaly in Europe.” Birth Defects Research, vol. 103, no. 9, 2015, pp. 763–71, https://doi.org/10.1002/bdra.23400.


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